Mesure de la superoxyde et de la dismutase sériques et pertinence de l'intensité du trouble chez les enfants autistes

Aperçu: G.M.

L'autisme est un trouble omniprésent et sa prévalence a augmenté dans les enquêtes récentes. On estime que 1 enfant sur 88 est affecté par l'autisme. Les symptômes du syndrome d'autisme apparaissent avant l'âge de trois ans. On pense que les taux sériques de superoxyde dismutase (SOD) peuvent jouer un rôle dans l'étiologie de l'autisme.

Le niveau moyen de SOD dans le groupe de traitement (1,04 ± 1,33 ng / ml) était significativement inférieur au groupe témoin (p = 0,001). Cependant, le niveau de SOD n'était pas significativement associé à la gravité de l'autisme (p = 0,667). Conclusions: La diminution des taux sériques de superoxyde dismutase dans le diagnostic précoce des enfants autistes peut être considérée comme un biomarqueur diagnostique. 

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Maedica (Buchar). 2015 Sep;10(4):315-318.

Measurement of Serum Superoxide Dismutase and Its Relevance to Disease Intensity Autistic Children

Mozhgan A¹, Sakineh S¹, Mohammad Reza K², Maryam H³.

Author information

1

Department of Biology, Faculty of Science, Damghan Branch, Islamic Azad University, Damghan, Iran.

2

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

3

Noor Hedayat, Center of Autism Spectrum Disorders, Mashhad, Iran.

Abstract

BACKGROUND:

Autism is a pervasive disorder and its prevalence increased in recent surveys. An estimated 1 out of every 88 children is affected by autism. Autism disorder symptoms appear before the age of three. It is believed that serum levels of superoxide dismutase may play a role in etiology of autism.

MATERIALS AND METHODS:

Between October and November 2014, 27 Iranian children from Mashhad city were selected in this study. Given these assumptions, the amount of SOD serum in autistic patients and healthy individuals and correlation between the amount of SOD and autism severity were examined. Blood samples of 30 autistic children and 18 age-matched healthy children were collected between 9 to 11 am. Serum level of SOD in both groups was measured by ELISA method.

RESULTS:

The mean SOD level in the treatment group (1.04 ±1.33 ng/ml) was significantly lower than the control group (p = 0.001). However, SOD level was not significantly associated with the autism severity (p = 0.667). Conclusions: Decreased serum levels of superoxide dismutase in the early diagnosis of autistic children can be considered as a diagnostic biomarker.

PMID: 28465731

PMCID: PMC5394433