Altérations liées au sexe de la composition de microbiote intestinal dans le modèle de souris BTBR du trouble du spectre de l'autisme

Aperçu: G.M.

Des modifications de l'axe du microbiote-intestin-cerveau ont été invoquées dans la pathogenèse des troubles du spectre de l'autisme (TSA). Les modèles de souris pourraient représenter un excellent outil pour comprendre comment la dysbiose intestinale et les modifications connexes peuvent contribuer au phénotype autistique.  

Nous avons identifié les genres Bacteroides, Parabacteroides, Sutterella, Dehalobacterium et Oscillospira comme facteurs clés des profils de microbiota intestinal spécifiques au sexe associés à certains traits pathologiques.  

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Sci Rep. 2017 Mar 28;7:45356. doi: 10.1038/srep45356.

Sex-related alterations of gut microbiota composition in the BTBR mouse model of autism spectrum disorder

Coretti L¹, Cristiano C², Florio E³, Scala G⁴, Lama A², Keller S³, Cuomo M³, Russo R², Pero R³, Paciello O⁵, Mattace Raso G², Meli R², Cocozza S^1,3, Calignano A², Chiariotti L^1,3, Lembo F².

Author information

1

Institute of Endocrinologia ed Oncologia Sperimentale, IEOS, Consiglio Nazionale delle Ricerche CNR, Via S. Pansini, 5, 80131, Naples, Italy.

2

Department of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131, Naples, Italy.

3

Department of Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, Via S. Pansini, 5, 80131, Naples, Italy.

4

Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Naples, Italy.

5

Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Napoli, Italy.

Abstract

Alterations of microbiota-gut-brain axis have been invoked in the pathogenesis of autism spectrum disorders (ASD). Mouse models could represent an excellent tool to understand how gut dysbiosis and related alterations may contribute to autistic phenotype. In this study we paralleled gut microbiota (GM) profiles, behavioral characteristics, intestinal integrity and immunological features of colon tissues in BTBR T + tf/J (BTBR) inbred mice, a well established animal model of ASD. Sex differences, up to date poorly investigated in animal models, were specifically addressed. Results showed that BTBR mice of both sexes presented a marked intestinal dysbiosis, alterations of behavior, gut permeability and immunological state with respect to prosocial C57BL/6j (C57) strain. Noticeably, sex-related differences were clearly detected. We identified Bacteroides, Parabacteroides, Sutterella, Dehalobacterium and Oscillospira genera as key drivers of sex-specific gut microbiota profiles associated with selected pathological traits. Taken together, our findings indicate that alteration of GM in BTBR mice shows relevant sex-associated differences and supports the use of BTBR mouse model to dissect autism associated microbiota-gut-brain axis alteration.

PMID: 28349974

DOI: 10.1038/srep45356