Aperçu: G.M.
L'âge
paternel avancé par rapport aux troubles du spectre de l'autisme et à la
schizophrénie a fourni les preuves épidémiologiques les plus robustes d'une association.
Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):202-213. doi: 10.1002/ajmg.b.32508. Epub 2016 Oct 22.
Paternal age and psychiatric disorders: A review
de Kluiver H1,2, Buizer-Voskamp JE3, Dolan CV1,2, Boomsma DI1,2,4.
Author information
- 1
- Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
- 2
- EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
- 3
- Department of Social and Behavioral Sciences, Utrecht University, Utrecht, The Netherlands.
- 4
- Neuroscience Campus Amsterdam, Amsterdam, The Netherlands.
Abstract
We
review the hypotheses concerning the association between the paternal
age at childbearing and childhood psychiatric disorders (autism spectrum- and attention deficit/hyperactive disorder) and adult disorders (schizophrenia, bipolar-, obsessive-compulsive-, and major depressive disorder)
based on epidemiological studies. Several hypotheses have been proposed
to explain the paternal age effect. We discuss the four main-not
mutually exclusive-hypotheses. These are the de novo mutation
hypothesis, the hypothesis concerning epigenetic alterations, the
selection into late fatherhood hypothesis, and the environmental
resource hypothesis. Advanced paternal age in relation to autism
spectrum disorders and schizophrenia provided the most robust
epidemiological evidence for an association, with some studies reporting
a monotonic risk increase over age, and others reporting a marked
increase at a given age threshold. Although there is evidence for the de
novo mutation hypothesis and the selection into late fatherhood
hypothesis, the mechanism(s) underlying the association between advanced
paternal age and psychiatric illness in offspring remains to be further
clarified. © 2016 The Authors. American Journal of Medical Genetics
Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
© 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.
- PMID: 27770494
- DOI: 10.1002/ajmg.b.32508
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