Est-ce que l'atopie dans la petite enfance est un facteur de risque pour le TDAH et le TSA? Une étude longitudinale

Traduction: G.M.

J Psychosom Res. 2014 Oct;77(4):316-21. doi: 10.1016/j.jpsychores.2014.06.006. Epub 2014 Jun 21.

Is atopy in early childhood a risk factor for ADHD and ASD? A longitudinal study

Chen MH¹, Su TP², Chen YS¹, Hsu JW¹, Huang KL¹, Chang WH¹, Chen TJ³, Pan TL⁴, Bai YM⁵.

Author information

• ¹Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.
• ²Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
• ³Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.
• ⁴School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
• ⁵Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan; Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan. Electronic address: ymbi@mail2000.com.tw

Abstract

OBJECTIVE:

Previous studies have found a temporal concordance in the increased prevalence of atopic diathesis/atopic diseases, attention-deficit hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD) worldwide. But, the temporal association among these 3 distinct diseases is unknown.
Des études antérieures ont montré une concordance temporelle dans la prévalence accrue du terrain atopique / maladies atopiques (Note de trad.: prédisposition génétique au développement d'allergie courantes), le trouble de l'attention avec hyperactivité (TDAH) et les troubles du spectre autistique (TSA) dans le monde entier. Mais, l'association temporelle entre ces trois maladies distinctes est inconnue. 

METHOD:

14,812 atopic subjects diagnosed with any atopic disease (asthma, atopic dermatitis, allergic rhinitis, or allergic conjunctivitis) before the age of 3 (atopic cohort) and 6944 non-atopic subjects with no lifetime atopic disease (non-atopic cohort), born between 1997 and 2000, were enrolled and followed to December 31, 2010 to identify the development of ADHD and ASD.

RESULTS:

The presence of any atopic disease in early childhood increased the risk of developing ADHD (hazard ratio [HR]: 1.97) and ASD (HR: 3.40) in later life. Greater numbers of atopic comorbidities (4 comorbidities: ADHD: HR: 2.53; ASD: HR: 4.29) were significantly related to a greater risk of developing ADHD and ASD.
La présence d'une maladie atopique dans la petite enfance augmente le risque de développer un TDAH (hazard ratio [HR]: 1,97) et TSA (HR: 3,40) plus tard dans la vie. Un plus grand nombre de comorbidités atopiques (4 comorbidités: TDAH: HR: 2,53; TSA: HR: 4,29) étaient significativement liées à un risque accru de développer le TDAH et le TSA. 

DISCUSSION:

Atopic diathesis in early childhood elevated the risk of developing ADHD and ASD in later life, with the dose-dependent relationship of more atopic comorbidities with a greater likelihood of ADHD and ASD.
Une diathèse atopique dans la petite enfance augmente le risque de développer un TDAH et un TSA dans la vie plus tard, avec la relation dépendant de la dose de comorbidités atopiques avec une plus grande probabilité de TDAH et TSA.

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID: 25280829