Traduction: G.M.
Front Cell Neurosci. 2014 Sep 29;8:309. doi: 10.3389/fncel.2014.00309. eCollection 2014.
Synapses as therapeutic targets for autism spectrum disorders: an international symposium held in pavia on july 4th, 2014
Curatolo P1, Ben-Ari Y2, Bozzi Y3, Catania MV4, D'Angelo E5, Mapelli L6, Oberman LM7, Rosenmund C8, Cherubini E9.
Author information
- 1Pediatric Neurology Unit, Department of Neurosciences, Tor Vergata University , Rome , Italy.
- 2Institut National de la Santé et de la Recherche Médicale, Mediterranean Institute of Neurobiology (INMED) , Marseille , France.
- 3CNR Neuroscience Institute and Laboratory of Molecular Neuropathology, Centre for Integrative Biology (CIBIO), University of Trento , Trento , Italy.
- 4CNR, Institute of Neurological Sciences (ISN) , Catania , Italy ; Laboratory of Neurobiology, Istituto di Ricovero e Cura a Carattere Scientifico Oasi Maria SS , Troina , Italy.
- 5Department of Brain and Behavioral Sciences, University of Pavia , Pavia , Italy ; Brain Connectivity Center, Neurological Institute Istituto di Ricovero e Cura a Carattere Scientifico Mondino , Pavia , Italy.
- 6Department of Brain and Behavioral Sciences, University of Pavia , Pavia , Italy.
- 7Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University , Providence, RI , USA.
- 8Neuroscience Research Center and NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin , Berlin , Germany.
- 9International School for Advanced Studies (SISSA) , Trieste , Italy ; European Brain Research Institute (EBRI) , Rome , Italy.
Résumé
De nouveaux progrès dans les mécanismes moléculaires et cellulaires de troubles du spectre autistique (TSA) ont été discutés lors de la journée du colloque international qui s'est tenu à Pavie (Italie) le 4 juillet 2014 intitulé «synapses comme cibles thérapeutiques pour les troubles du spectre autistique" (satellite de la FENS Forum for Neuroscience, Milan, 2014).En particulier, les experts mondiaux du domaine ont mis en évidence la façon dont les modèles animaux de TSA ont considérablement fait progresser notre compréhension des mécanismes moléculaires impliqués dans le dysfonctionnement synaptique conduisant parfois à des «essais cliniques synaptiques» chez les enfants.
Abstract
New progresses into the molecular and cellular mechanisms of autism
spectrum disorders (ASDs) have been discussed in 1 day international
symposium held in Pavia (Italy) on July 4th, 2014 entitled "synapses as
therapeutic targets for autism
spectrum disorders" (satellite of the FENS Forum for Neuroscience,
Milan, 2014). In particular, world experts in the field have highlighted
how animal models of ASDs have greatly advanced our understanding of
the molecular pathways involved in synaptic dysfunction leading
sometimes to "synaptic clinical trials" in children.
- PMID: 25324723
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