Le régime kétogène et les troubles neurologiques de l'enfance autres que l'épilepsie: une vue d'ensemble

Aperçu: G.M.

Au cours des dernières années, le régime kétogène (KD) a été utilisé expérimentalement dans divers troubles neurologiques de l'enfance tels que les mitochondriopathies, l'hémiplégie alternée de l'enfance (AHC), les tumeurs cérébrales, la migraine et le trouble du spectre de l'autisme (TSA).

L'étude visait à analyser comment le KD peut cibler ces différentes conditions médicales, mettant en évidence les possibles mécanismes impliqués.

Le KD pourrait améliorer les compétences cognitives et sociales dans un sous-ensemble d'enfants avec un diagnostic de TSA

Expert Rev Neurother. 2017 May;17(5):461-473. doi: 10.1080/14737175.2017.1260004. Epub 2016 Nov 21.

Ketogenic diet and childhood neurological disorders other than epilepsy: an overview

Verrotti A¹, Iapadre G¹, Pisano S², Coppola G³.

Author information

1

a Department of Pediatrics , University of L'Aquila, San Salvatore Hospital , L'Aquila , Italy.

2

b Department of Child and Adolescent Neuropsychiatry , University of Salerno , Salerno , Italy.

3

c Department of Child Neuropsychiatry , University of Salerno , Salerno , Italy.

Abstract

INTRODUCTION:

In the last years, ketogenic diet (KD) has been experimentally utilized in various childhood neurologic disorders such as mitochondriopathies, alternating hemiplegia of childhood (AHC), brain tumors, migraine, and autism spectrum disorder (ASD). The aim of this review is to analyze how KD can target these different medical conditions, highlighting possible mechanisms involved. Areas covered: We have conducted an analysis on literature concerning KD use in mitochondriopathies, AHC, brain tumors, migraine, and ASD. Expert commentary: The role of KD in reducing seizure activity in some mitochondriopathies and its efficacy in pyruvate dehydrogenase deficiency is known. Recently, few cases suggest the potentiality of KD in decreasing paroxysmal activity in children affected by AHC. A few data support its potential use as co-adjuvant and alternative therapeutic option for brain cancer, while any beneficial effect of KD on migraine remains unclear. KD could improve cognitive and social skills in a subset of children with ASD.

PMID: 27841033

DOI: 10.1080/14737175.2017.1260004