Prenatal stress increases the striatal and hippocampal expression of correlating c-FOS and serotonin transporters in murine offspring

Traduction partielle: G.M.

Int J Dev Neurosci. 2014 Aug 4. pii: S0736-5748(14)00114-2. doi: 10.1016/j.ijdevneu.2014.07.006. [Epub ahead of print]

Le stress prénatal augmente l'expression du striatum et l'hippocampe de corrélation c-fos et transporteurs de la sérotonine dans la progéniture de souris

Bielas H1, Arck P2, Bruenahl CA3, Walitza S4, Grünblatt E4.

Author information

• 1University Clinics of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland; Department of Psychosomatics and Psychiatry, University Children's Hospital Zurich, Zurich Switzerland. Electronic address: hannes.bielas@kispi.uzh.ch.
• 2Laboratory for experimental Feto-Maternal Medicine, University Medical Center Hamburg, Hamburg, Germany.
• 3Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg, Hamburg, Germany.
• 4University Clinics of Child and Adolescent Psychiatry, University of Zurich, Neumünsterallee 9, 8032 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland.

Abstract

Prenatal stress (PS) is a known risk factor for several psychiatric diagnoses, including schizophrenia, attention deficit hyperactivity disorder, autism, anxiety, and depression which have been associated with serotonin transporter (SERT) dysregulation. 

Le stress prénatal (SP) est un facteur de risque connu pour plusieurs diagnostics psychiatriques, comme la schizophrénie, le trouble de déficit d'attention avec hyperactivité, l'autisme, l'anxiété et la dépression qui ont été associés au dérèglement du transporteur de la sérotonine (SERT).

Moreover, long-term effects in animal models associate with higher levels of immediate early genes, e.g. c-FOS (up-regulated in response to neuronal activity), in the brain of PS offspring. 

En outre, les effets à long terme dans les modèles animaux sont associés avec des niveaux plus élevés de gènes précoces immédiats, par exemple, c-FOS (sur-régulateur de la réponse à l'activité neuronale), dans le cerveau de progéniture SP.

We therefore quantified the expression of both protein related mRNAs in adolescent BALB/c mice subjected to mild auditory stress on two separate days in mid gestation. SERT and c-FOS consistently correlated in most brain regions of PS mice and controls. Moreover, two-way ANOVAs revealed concomitantly increased levels of proteins, as well as of FOSL1 and FOSL2 mRNA, especially in the striatum and hippocampus of the PS offspring. Sex affected only and less consistently mRNA expression, yet interacted with PS, demonstrating that glucocorticoid receptor mRNA expression decreased in PS males but increased in PS females compared to the respective controls. 

This first finding of a correlation between SERT and c-FOS protein expression affected by PS, together with related mRNAs, may be considered a new target for behavioral and treatment studies in offspring.

Ce premier constat d'une corrélation entre le SERT et l'expression de la protéine c-FOS affectée par PS, avec les ARNm connexes, peut être considéré comme une nouvelle cible pour des études comportementales et de traitement de la progéniture. 

Copyright © 2014. Published by Elsevier Ltd.

PMID: 

25102410