Perinatal and background risk factors for childhood autism in central China

Traduction: G.M.

Psychiatry Res. 2014 Jun 24. pii: S0165-1781(14)00478-8. doi: 10.1016/j.psychres.2014.05.057. [Epub ahead of print]

Facteurs de risque liés au milieu et périnatals pour l'autisme infantile dans le centre de la Chine

Duan G1, Chen J2, Yao M3, Ma Y4, Zhang W4.

Author information

• 1Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China; Center of Children Psychology and Behavior, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
• 2Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China. Electronic address: hydgq@sina.com
• 3Center of Children Psychology and Behavior, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
• 4Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China.

Abstract

Perinatal and background risk factors for autism were identified in a cohort of autistic children in Zhengzhou, China, to formulate preventative and treatment strategies for high-risk families. 

Les facteurs de risque périnatals et environnementaux de l'autisme ont été identifiés dans une cohorte d'enfants autistes à Zhengzhou, en Chine, afin de formuler des stratégies de prévention et de traitement pour les familles à haut risque. 

In this case-control study, children were screened for suspected autism using the Autism Behavior Checklist (ABC) and diagnosed according to DSM-IV and the Childhood Autism Rating Scale (CARS). We collected perinatal histories and clinical data of 286 confirmed autistic children treated at the Third Affiliated Hospital Children׳s Psychological Clinic of Zhengzhou University from 2011 to 2013. The control group consisted of 286 healthy children from area kindergartens. Maternal age>30 years, parental introversion as measured by the Eysenck Personality Questionnaire, low level of parental education, smoking, abortion threat, pregnancy complications, maternal illness during pregnancy, maternal mental health, family history of mental illness, neonatal jaundice, birth asphyxia, premature rupture of the fetal membrane, and gestational age<37 weeks were significantly higher in the autism group. These factors were significantly correlated with behavioral symptoms as measured by ABC scores (Kendall rank correlation). 

Birth asphyxia, neonatal jaundice, maternal age, parental introversion, family history of mental illness, abortion threat, premature delivery, and smoking were identified as independent risk factors by multivariate logistic regression.

L'asphyxie à la naissance, l'ictère néonatal, l'âge maternel, l'introversion des parents, les antécédents familiaux de maladie mentale, menace d'avortement, l'accouchement prématuré et le tabagisme ont été identifiés comme des facteurs de risque indépendants par régression logistique multivariée.

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KEYWORDS:

Central China; Childhood autism; Perinatal risk factors

PMID:

 

25085792